Cancer research and the family history of the disease
Cancer research reports that relatives of women whose breast cancer was detected before the age of 35 are at risk of developing other malignant tumors, researchers from the University of Melbourne reported in a new article.
Relatives of women whose breast cancer was detected before the age of 35 are exposed to the increased risk of developing other malignant tumors, researchers from the University of Melbourne also reported on cancerresearch. The researchers were surprised by the results and suggest that they may indicate a new hereditary syndrome of cancerous diseases.
Australian researchers report that, given the results, there may be unidentified genes that lead to the development of breast cancer in these women, and possibly other malignant diseases among their family members.
The presence of a family relative with breast cancer is an important and known risk factor for the onset of the disease, and the severity varies depending on the number of relatives and the degree of proximity to the patient, as well as the patient's age at the onset of the disease. In a previous survey, it was found, on average, that having a first-rate, breast cancer would increase the risk of breast cancer twice. When there are two first-class relatives with the disease, the risk of contracting the disease is three times higher and four times higher when there are three breast cancer patients. This increase in risk mainly emerges among young women and among female relatives of at least one woman who has been diagnosed at an early age.
Most studies have focused on the risk of malignant diseases of the breast at all ages, so little is known about the risks of breast cancer when there is a family relative who has been diagnosed at a very young age, such as women who have been diagnosed before age 35, and also does not know what is the risk of disease Other malicious.
In a search for cancer, researchers examined 2200 parents and siblings of 500 women who were diagnosed with breast cancer before the age of 35 from three countries, Australia, Canada and the United States. After taking out families with mutations in BRCA1 and BRCA2genes, the two basic genetic mutations of breast cancer, researchers found that the relatives of women who had breast cancer at a young age increased their risk of infection not only breast cancer, but also malignant diseases In the prostate, lung, brain and urinary tract.
The results suggest that parents and siblings have a five-fold increase in the risk of prostate cancer. Mothers and sisters of women who have contracted the disease before age 35 have twice the risk of ovarian cancer as well as a 4-fold increase in the risk of breast cancer. Relatives have been detected a B-3-fold increase in the risk of developing brain cancer, an eight-fold increase in the risk of lung cancer and an increase of B-4 times the risk of malignant tumors in the urinary tract.
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The researchers wanted to know what was causing the early onset of breast cancer among these women and found results they did not expect about the relatives of these women who had contracted the disease before age 35.
The results of the research provide evidence of family factors, such as changes in genes other than BRCA1 and BRCA2, that can contribute to the increased risk of malignant diseases in the breast, prostate, lung and/or brain, among relatives of women who have had breast cancer at an early age. These findings may help researchers identify new genes that increase the risk of malignant diseases, which may help to understand the risk of early onset cancers and other malignant tumors occurring in the same family.
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